The project’s activities are organised into the following 8 workpackages:

WP1: Users and system requirements
The workpackage has the following objectives:
• Definition of the protocols for signal acquisition
• Identification and development of computerised cognitive mood and emotional tests
• Definition of user needs and system requirements
• Definition of testing protocols for clinical validation

WP2: Hardware platform for multi parametric monitoring
The workpackage is responsible for the implementation of the remote sensing platform and instrumented patches, the sensor modules, real-time algorithms and the portable devices to gather parameters correlated to psycho-emotional patient status. Different systems will be delivered for laboratory and naturalistic monitoring, for day and night use. Each system includes textile and non-textile sensors, and wearable electronics with the aim to increase the number of acquired physiological and mood correlated measurements without interfering with the patients in terms of comfort as well as motivation. This WP will provide state of art technology to be used during the Acquisition Phase in laboratory and natural environment to build the database for the implementation of software PSYCHE platform.

WP3: Signal processing and parameter extraction
One of the main objectives of this project is to relate physiological and behavioral signals to bipolar state in order to derive a quantitative and measurable indicator of this state. The first step for the derivation of such an indicator is to extract relevant features from measured signals. The analysis for the feature extraction will be based on models which describe how the nervous system regulates the values of the measured signals in different environment conditions and how bipolar disorder may affect this regulation process. This WP is required to define, to implement and to verify several methods of signal and data processing of peripheral and central physiological signals, including activity and gesture, biochemical data, ECG EMG, EOG, respiration activity, internal temperature, and clinical evaluations. The objective is to identify a set of parameters related to the bipolar state. Among the identified parameters a subset will be chosen that will be candidate for the implementation on the naturalistic environment monitoring system. The final aim is to provide tools that are a decision-making support for the early identification of the state changes in the daily life environment of the patient.

WP4: Data Mining and data managing
The goal of this workpackage is to design and develop a proper DSS that will make possible to interpret the patient bioinformation, to assist the physician in his decision and to interact with the patient behavior. This workpackage is also responsible for the development and implementation of algorithm for acquiring structural data, knowledge discovery and knowledge interpretation by using methods from artificial intelligence, machine learning, statistics, and research on databases. The workpackage will define and implement intelligent techniques to predict patient evolutions and define possible solution before irreparable events. The workpackage will provide visual information interpretation and interpretation to support medical professionals, healthy interested persons and relatives as well as patients suffering in bipolar disorders.

WP5: User and Professional Interface
WP5 aims at designing and developingthe user interaction workflows and the user interfaces for both patients and professionals. User interaction design is based on the creation of user models that will drive the development of the interaction solutions. These models are based on the definition of a comprehensive set of parameters that describe the status of the patient in a specific moment in time, which set of parameters and the environmental conditions will be defined in the frame of WP1 activity. The accuracy of these parameters is especially important when designing for bipolar patients, as the interaction will be different whether the patientis in a depressive mood or entering a maniac phase, which can be controlled via the index of bipolar state. Moreover, when designing user interaction for chronic patients, it is important not to focus only on the patient, but to perform a holistic approach that takes into account the patient’s social, medical and professional environments.

WP6: Validation through Clinical Application
The first goal of this workpackage is to document the ability of the PSYCHE system to predict significant clinical events in patients with bipolar mood disorders such as:
• response to treatment
• recurrence of a new episode or of a period at risk of recurrence or of mood changes

The second goal of this workpackage is to document the acceptability and the usability of the PSYCHE system by the patients suffering from bipolar disorders.

WP7: Dissemination and Business Assessment
The objective of this work package is to protect projects results, to manage communication of the results to the user community, and to ensure market awareness for PSYCHE. It will be organised into the following streams of activity:
• Intellectual properties management
• Dissemination of scientific results
• Dissemination and financial exploitation through the community-web2.0
• Preparation for Commercialization of PSYCHE results

WP8: Project Management
The objective of this WP is twofold:
1) to plan, monitor and apply corrective actions in response to deviations concerning project work and resources, and 2) to manage all communication between project consortium and the Commission.